A stomatin-like protein necessary for mechanosensation in C. elegans
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Auteurs : Mingxia Huang ; Guoqiang Gu [États-Unis] ; Edwin L. Ferguson ; Martin ChalfieSource :
- Nature [ 0028-0836 ] ; 1995-11-16.
Abstract
The mec-2 gene is required for the function of a set of six touch receptor neurons in the nematode Caenorhabditis elegans; mec-2 mutants, which are touch-insensitive, have touch cells that appear morphologically normal1,2. Gene interaction studies suggest that mec-2 positively regulates the activity of the putative mechano-sensory transduction channel (ref. 3 and the present paper), comprised in part of proteins encoded by the two degenerin genes mec-4 and mec-10 (refs 35). The central region of the mec-2 protein(MEC-2) is very similar to stomatin, an integral membrane protein (band 7.2b) in human red blood cells that is thought to regulate cation conductance6. MEC-2-LacZ fusions are distributed along the touch receptor axons. This axonal distribution, which is mediated by the mec-2-specific amino terminus, is disrupted by mutations in mec-12, an -tubulin gene needed for touch cell function. Our results indicate that MEC-2 links the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Such linkage provides the basis for a mechanismof mechanosensation whereby microtubule displacement leads to channel opening.
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DOI: 10.1038/378292a0
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Ferguson</name></author><author><name sortKey="Chalfie, Martin" sort="Chalfie, Martin" uniqKey="Chalfie M" first="Martin" last="Chalfie">Martin Chalfie</name></author></analytic><monogr></monogr><series><title level="j" type="main">Nature</title><imprint><publisher>Nature Publishing Group</publisher><date when="1995-11-16">1995-11-16</date><biblScope unit="vol">378</biblScope><biblScope unit="issue">6554</biblScope><biblScope unit="page" from="292">292</biblScope><biblScope unit="page" to="295">295</biblScope><date type="Copyright" when="1995">1995</date></imprint><idno type="ISSN">0028-0836</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The mec-2 gene is required for the function of a set of six touch receptor neurons in the nematode Caenorhabditis elegans; mec-2 mutants, which are touch-insensitive, have touch cells that appear morphologically normal1,2. Gene interaction studies suggest that mec-2 positively regulates the activity of the putative mechano-sensory transduction channel (ref. 3 and the present paper), comprised in part of proteins encoded by the two degenerin genes mec-4 and mec-10 (refs 35). The central region of the mec-2 protein(MEC-2) is very similar to stomatin, an integral membrane protein (band 7.2b) in human red blood cells that is thought to regulate cation conductance6. MEC-2-LacZ fusions are distributed along the touch receptor axons. This axonal distribution, which is mediated by the mec-2-specific amino terminus, is disrupted by mutations in mec-12, an -tubulin gene needed for touch cell function. Our results indicate that MEC-2 links the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Such linkage provides the basis for a mechanismof mechanosensation whereby microtubule displacement leads to channel opening.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><noCountry><name sortKey="Chalfie, Martin" sort="Chalfie, Martin" uniqKey="Chalfie M" first="Martin" last="Chalfie">Martin Chalfie</name><name sortKey="Ferguson, Edwin L" sort="Ferguson, Edwin L" uniqKey="Ferguson E" first="Edwin L." last="Ferguson">Edwin L. Ferguson</name><name sortKey="Huang, Mingxia" sort="Huang, Mingxia" uniqKey="Huang M" first="Mingxia" last="Huang">Mingxia Huang</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Gu, Guoqiang" sort="Gu, Guoqiang" uniqKey="Gu G" first="Guoqiang" last="Gu">Guoqiang Gu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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